Design Synthesis spectroscopic studies and Preliminary Antibacterial Evaluation of Schiff Base derivative from sulfadiazine and cephalexin and its metal complexes

AbstractKey wordsDOI
Metal(II) chelation components of new tridentate ligand of Schiff base gotten from the reaction of sulfadiazine and cephalexin antibiotics with Cu(II), Co(II), Ni(II), Zn(II)ions with general formula [MLc(H2O)3] where L =(C26H25N7O5S2) have been prepared. The compounds have been depicted by 1H- NMR, UV, mass and FT-IR spectroscopy and calculations of molar conductivity, magnetic sensitivity, and macro- and TGA analysis. All the compounds have been disclosed both for microbiological efficiency in vitro versus two (-)ive gram and two (+)ive gram bacteria. The [NiLc(H2O)3] complex was appeared to be more efficient than the free[HLc]. The values of molar conductance and analytical mentioned which the ligand conducts as a tridentate NNO coordinating in the mono complexes.
magnetic; spectral; synthesis; cephalexin; tridentate
DOI: 10.52113/2/08.02.2021/55-67
Zaid Mohammed Ali 1 and Rehab Kadhim Raheem Al-Shemary 2,* Received 4-10-2020, Accepted 22-12-2020, published 31-12-2021.
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