Design Synthesis spectroscopic studies and Preliminary Antibacterial Evaluation of Schiff Base derivative from sulfadiazine and cephalexin and its metal complexes

Zaid Mohammed Ali 1 and Rehab Kadhim Raheem Al-Shemary 2,*

1,2 Department of Chemistry, College of Education for Pure Science, Ibn -Al-Haitham, University of Baghdad. Italic)
*Corresponding Author: drrehabalshemary@gmail.com

DOI: 10.18081/2226-3284/22-12/55-67

AbstractKey words
Metal(II) chelation components of new tridentate ligand of Schiff base gotten from the reaction of sulfadiazine and cephalexin antibiotics with Cu(II), Co(II), Ni(II), Zn(II)ions with general formula [MLc(H2O)3] where L =(C26H25N7O5S2) have been prepared. The compounds have been depicted by 1H- NMR, UV, mass and FT-IR spectroscopy and calculations of molar conductivity, magnetic sensitivity, and macro- and TGA analysis. All the compounds have been disclosed both for microbiological efficiency in vitro versus two (-)ive gram and two (+)ive gram bacteria. The [NiLc(H2O)3] complex was appeared to be more efficient than the free[HLc]. The values of molar conductance and analytical mentioned which the ligand conducts as a tridentate NNO coordinating in the mono complexes.
magnetic; spectral; synthesis; cephalexin; tridentate

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