Synthesis of Azo Derivatives Linked 1,2,3-Triazols Ring and Study of Their Biological Activity

In this study, a series of azo derivatives incorporating a 1,2,3- triazole moiety were synthesized and evaluated for biological activity. The synthetic pathway began with N,N-diaminodiphenylmethane, which was diazotized using sodium nitrite (NaNO₂) and hydrochloric acid, by coupling with 1-methyl-1H-1,2,3-triazole-4-carbaldehyde in the presence of sodium hydroxide (NaOH) to yield the azo compound. This azo compound was then reacted with p-aminoacetophenone in ethanol, using NaOH as a catalyst, to form a chalcone derivative. Subsequent reactions were carried out under reflux conditions with urea (in basic medium), phenylhydrazine (using a little of glacial acetic acid as catalyst), and hydrazinium hydroxide to obtain Oxazine and pyrazole derivatives, respectively. Structural confirmation of the prepared compounds was thorough using FT-IR, ¹³C-NMR, and ¹H-NMR spectroscopy. Biological screening revealed that all synthesized compounds exhibited promising antimicrobial activity.

Azo derivative, triazol ring , N,N-diaminodiphenylmethan , chalcone, synthesis , biological activity.

10.52113/2/12.01.2025/104-116